Muscatatuck National Wildlife Refuge is located in south central Indiana. The refuge takes its name from the Muscatatuck River, which forms the southern boundary.
Traversing 303 miles through the lush hills and farmlands of southern Indiana and paralleling the mighty Ohio River, this route marks a time-worn and history-rich corridor linking historic villages and farms through a picturesque landscape.
In an area rich in Indian history, the 3, 180 acre Mississinewa Lake includes both State and Corps managed recreation areas. The name, "Mississinewa" was derived for the Miami Indian word for "water on a slope.